Under the complex influence of human activities and climate change, the rainfall characteristics of Dongjiang River Basin have changed significantly in recent 66 years. In order to accurately identify the temporal and spatial variation characteristics of multi-year rainfall in Dongjiang River Basin, based on the monthly long-series rainfall data of Dongjiang River Basin, the annual distribution characteristics of rainfall in Dongjiang River Basin, the trend, mutation and periodic characteristics and the spatial variation law were analyzed from multiple angles by using various methods such as concentration degree, concentration period, OLS regression method, Mann-Kendall method, sliding T test method and one-dimensional continuous wavelet. The results show that the rainfall in Dongjiang River Basin decreases from northeast to southwest; From upstream to downstream, the rainfall concentration period is postponed from June to July, and the trend of rainfall changes from decreasing to weak increasing. The mutation of downstream rainfall is more significant than that of upstream , and the cycle period of upstream rainfall is stronger than that of downstream. The main cycle period of upstream and downstream rainfall is the same, and 17a is the main cycle of basin rainfall. The research results can provide support for related research such as rainfall forecast and water resources development and utilization in Dongjiang River Basin.