Abstract: The rapid development of domestic high-resolution satellites can effectively compensate for the low special resolution in lake monitoring with remote images, and realize dynamical monitoring on Lake without delay and better accuracy. This paper took 155 Landsat imagines during 1996-2012 and 34 GF images during 2013-2016 as the data sources, modified normalized difference water index (MNDWI) and normalized difference water index (NDWI) were chosen to extract the water area in remote sensing images combined with the water level data at Hukou station. At the same time, the method of statistical analysis was established to build different water area-water level models in four seasons. The results show that the water area of Poyang Lake has a gradually declining trend in space, and it shows obvious decrease in autumn while slight change in other seasons. The relationship between water area and water level of Poyang Lake is suitable for quadratic function model after data validation.