The meteorological factors and runoff in the Babaohe basin of Qilian Mountains have responded positively to the climatechange. The annual mean air temperature has risen greatly with the increase of 0.35℃ per 10a from the linear trend during 1968-2012， which is three times of the world average rate. Besides， the annual precipitation has risen slightly with the increase of1.5% per 10a while the annual runoff has risen significantly with the increase of 5.2% per 10a. Generally， the annual runoff isdominated by precipitation that is categorized into 3 phases. In the wet season， the intensively increased temperature has slightlyaffected the runoff while the slightly increasing precipitation has significant correlation with the increasing runoff. However， verylimited solid precipitation has no effect on the runoff in the dry season. The obviously increasing runoff has been dominated by thedecrease of frozen ground depth and the increase of soil aquifer that caused by the intensively increase of temperature.