It is difficult to use traditional methods making hydrological predictions in Tibet Plateau because of the sparse distribution of hydrome -try stations and lack of observation data. By employing hydrological classification, the limited data of the hydrologic stations can be extrapolated tothe ungaged catchments with similar hydrological attributes. This paper took the Yarlung Zangbo River Basin as the study area, and fulfilled hy -drological classification based on the meteorological data, soil texture, land use, topography and other physical factors. The method of principalcomponent analysis and K-M clustering analysis were adopted. The whole basin was divided into five parts including alpine desert area, plateautemperate valley area, plateau gorge area, plateau glacier rain and snow zone, and subtropical mountain rain zone. In this paper, the differenceand similarity of the hydrological characteristics among the various areas were discussed. And the results of hydrological classification werechecked by Smirnov test. The results can provide a reference for hydrologic predication in the Yarlung Zangbo River Basin.