The purpose of the paper is to study the variation trend of groundwater dynamic in Da'an City and analyze the degree of the influences on it. According to the data of climate and surface water irrigation, groundwater exploitation, and groundwater depth, this paper analyzed the tendency of environmental factors and the temporal and spatial evolution of the groundwater depth by means of suffer software and kriging methods, and then identified the main factors for deriving change in groundwater depth. The results show that the precipitation presents a fluctuated increasing trend and its average increase slope is 0.249mm/a, the evaporation shows a fluctuated decreasing trend and its average decrease slope is -2.063mm/a, the irrigation areas tend to a great increase and its average increase slope is 17.933acre/a. The unconfined groundwater depth exhibits a less decline tendency and its average decrease slope is -0.023m/a, and the confined groundwater depth presents a fluctuated increasing trend and its average increase slope is 0.146m/a. The main driving factors of confined groundwater dynamics are as follows: groundwater exploitation, surface water irrigation, precipitation, evaporation, and the groundwater withdrawal for agricultural irrigation is the most important factor. The study results could provide theoretical support for policymakers to develop comprehensive program of configuration control of water resource.