Hydraulic impact for migration process of groundwater imposed by aquitard is different from the general aquifer. In this paper, theresearch advances in chemical osmosis of aquitard was tracked. It was found that indoor test is still the main method for researching in this field,the permeability test of different solution confirmed that aquitard with semi permeable membrane function, and it can filter out some salt. In-situtests have been carried out mainly in mudstone, shale’s permeability, less on the permeability of clay. Foreign scholars have carried out numerical simulations study for chemical penetration, using of a joint hydraulic driver and chemically driver model, to analyze some indicators characteristics. In future, in-situ chemical osmosis and reverse osmosis test in high precision will become a main research direction in this field.