The regional and interannual change characteristics of three elements were analyzed based on the observed da - ta of temperature, precipitation and evaporation from the 10 hydrometry stations in the upper and middle reaches of the eastern sub-rivers in the Heihe River Basin in the recent 60 years. The results show: (1) The mean annual temperature gradually increased with the altitude from the south to north decreasing, and the temperature increased by 0.9℃ in average since 2000. (2) The mean annual precipitation gradually decreased gradually with the altitude from the south to north and from the east to west decreasing. The precipitation hydrographs of the stations are serrated in high-frequency oscilla - tion over the years. The precipitation has a long trend of slow increase in the deep mountain area and plain of corridor (edges of desert), while the precipitation has a trend of slow decrease in the hilly area. (3) The geographical distribution of the evaporation is closely related with the precipitation and temperature distribution, and the mean annual evaporation gradually increased with the altitude from the south to north decreasing. There was no big change of the mean annual e - vaporation in the deep mountain area from 1980 to 2011, while there was a trend of evaporation decreasing in the hilly area and plain of corridor