The Yellow River is the source for drinking water, industrial and agricultural water use in Sanmenxia City. With the development of economic society and intensely growing of human activities, the Yellow River water pollution becomes serious. In order to size up the situation of the Yellow River drinking water source pollution in Sanmenxia City, and refer to Standard GB3838-2002 and observed data of water quality from 2004 to 2012, we made an analysis of the Yellow River drinking water source quality. The results show that the water source is at grade V-Ⅳ, the main pollution items include ammonia nitrogen and COD, so this paper put forward to strengthen the drinking water source monitoring, seek for pollution causes and adopt effective measures to control worsen quality of local water source.