In order to ensure the safety of drinking water in the southwest Shandong Province where residents use high-fluoride groundwater as drinking water. Target areas where groundwater matches the drinking water standard was delimited based on hydrogeological survey, analysis of water quality and comprehensive evaluation of water quality. According the water target areas and combing the distribution of other water resource, water supply status and type of water supply, three kinds of water supply modes were developed in different areas. The first one is centralized water supply mode which use shallow porous water or karst fissure water as drinking water and domestic water. The second one is dual water supply mode which use deep porous water as drinking water and supply shallow porous water as domestic water. The last one is centralized water supply mode which use surface water as the main resource of drinking water and domestic water. These water supply modes could be referred by future detailed projects to prevent resident from suffering high-fluoride water.