This paper analyzed the runoff data of the Hailiutu River, the middle reach of the Yellow River, from 1957 to 2007 with various methods.. According to the analysis by the non-uniform coefficient method of annual streamflow distribution, the annual runoff distribution of the Hailiutu River is quite uniform with a low concentration ratio. The annual runoff series was found to have a significant descending trend by using the Mann-Kendall test. And it was found that the precipitation in the same period has not obvious with non-uniform distribution of the annual precipitation. The precipitation concentrated in July, October and September. With the regime shift index (RSI) method, it was found that the annual runoff change can be divided into the durations as follows: 1957~1967，1968~1988，1989~2000，2001~2007. By comparising the trend and annual distribution of the runoff and precipitation, the conclusoin was made that there is no obvious impact of precipitation on runoff in the Hailiutu River Basin.