This paper introduces some anti-interference methods to be taken in communication design for hydrologic telemetering system according to VHF/UHF Telecommunication Circuit Design Manual, which include parameters adjusting for the system equation, selection of proper working frequency, selection of equipment parameters appropriate for anti-interference, making full use of the antenna's anti-interference function. In design of telecommunication circuit of hydrologic telemetering system, it is important to take anti-interference measures and improve the equipment function in anti-interference, which should be paid attention to.